Insecticide Resistance in West Africa
Understanding the impact of insecticide resistance on the efficacy of IRS and LLIN in Mali, Benin and Nigeria
Why this project?
Malaria is an important health issue in several West African countries, where it is a leading cause of morbidity and mortality. Across Africa, long-lasting insecticidal nets (LLINs) treated with pyrethroids and bendiocarb-based indoor residual spraying (IRS) are the key tools used for malaria control. However, populations of Anopheles species have developed resistance to insecticides used for mosquito control.
This research project analysed the effects of insecticide resistance developed by Anopheles species on the efficacy of malaria vector control tools (LLINs and IRS) in three West African countries – Mali, Benin and Nigeria.
The aim
The aim of this two-year study has been to assess how well IRS and LLINs work in sites where Anopheles species have developed resistance to insecticides.
Objectives
Update data on insecticide-stance and determine resistance mechanism(s) in the three target countries in order to identify appropriate study sites where vectors harbour knock-down and metabolic-based resistance mechanisms.
Monitor entomological, parasitological and socio-anthropological indices of LLINs/IRS efficacy in selected study sites with and without insecticide resistance.
Compare the performances of LLINs and IRS on entomological indices and malaria prevalence in localities where Anopheles exhibit knock-down resistance, metabolic-based resistance or both resistance mechanisms.
The research sites
Mali
Koula and Karadiè in Koulikoro District, and N’Galamadibi and Kolondialan in Banamba District
Nigeria
The study sites in Nigeria are in Ikorodu District in South Western Nigeria, on the outskirts of Lagos: Imota, Bayeku, Oreta and Igbokuta (control village)
Benin
Kpome and Ketonou
